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KMID : 0381219800120020161
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Journal of RIMSK
1980 Volume.12 No. 2 p.161 ~ p.168
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The Effects of Acute Acid-Base Disturbances on the Cerebrospinal Fluid pH in Dogs
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Abstract
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The changes in pH and [HCO3-] in CSF of anesthetized, curarized dogs during acute metabolic acidosis were compared with those changes when the blood acid-base parameters were kept at a normal level. Both groups were mechanically ventilated to maintain a constant Pa co2 The pH, Pc02 in CSF and arterial blood were measured at intervals and [HCO3-] in CSF and arterial blood were caculated from Henderson-Hasselbalch equation.
The electrical potential difference(E) between CSF and arterial blood were not measured in this experiments but the electrochemical potential differences(?) for H+ and HC03- were calculated from measured electrical potential differences in the dog under compatible experimental conditions.
Following control measurements at pH=7.4, metabolic acidosis was induced by infusion of 0. 6N HCl.
Measurements were made at 0, 60, 90,120 and 180 minutes thereafter and at 0, 60,120 and 180 minutes in the control series.
The results are as follows;
1) Prior to the infusion of acid, cerebrospinal fluid [H+] and Pco2were significantly higher than those of arterial blood respectively.
2) Under normal circumstances the CSF has been found to be 4mV positive to blood and the electrochemical potential differences for H+ and HC03- between blood and CSF were 9. 0 -9.5mV and 0.2-1.OmV respectively.
3) A significant increase in CSF [H+] was observed 90min. after the acid infusion and CSF pH was maintained within narrower limits than that of the blood.
4) During sustained metabolic acidosis, the difference of Pco2 between CSF and blood was not found to be increased but the CSF [HCO3-] was gradually decreased.
5) The closeness of 3-h values of ?H+ and ?nco3- to control was not found, but they showed the tendency to be returned to control gradually.
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KEYWORD
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